![]() Another study has reported 60% sensitivity and 88% specificity of thrombocytopenia for malaria diagnosis in acute febrile patients (Lathia & Joshi 2004). The presence of thrombocytopenia in acute febrile travellers returning from tropical areas has become a highly sensitive clinical marker for malaria diagnosis (D'Acremont et al. In the current field of Travel Medicine, the rapid increase in the number of people travelling to tropical areas has added a great challenge for malaria diagnosis because the thick blood smear (the standard diagnosis in endemic areas) has high specificity but only when performed by experienced microscopists. On the other hand, thrombocytopenia is less studied, causes negligible mortality and is an isolated phenomenon there is no report of a single patient in the literature who has died only because of malaria-associated thrombocytopenia. Anaemia and thrombocytopenia are the most frequent malaria-associated haematological complications (Wickramasinghe & Abdalla 2000) and have received more attention in the scientific literature due to their associated mortality. Malaria affects almost all blood components and is a true haematological infectious disease. Key words: Plasmodium falciparum - Plasmodium vivax - malaria - thrombocytopenia - platelets More studies are needed to specifically clarify if thrombocytopenia is the cause or consequence of the clinical disease spectrum. In most cases, a conservative approach is adopted and platelet counts usually revert to normal ranges a few days after efficacious antimalarial treatment. Data from experimental models are presented and, despite not being rare, there is no clear recommendation on the adequate management of this haematological complication. The speculated mechanisms leading to thrombocytopenia are: coagulation disturbances, splenomegaly, bone marrow alterations, antibody-mediated platelet destruction, oxidative stress and the role of platelets as cofactors in triggering severe malaria. vivax infection and may be explained by medullary compensation with the release of mega platelets in the peripheral circulation by megakaryocytes, thus maintaining a good primary haemostasis. Minor bleeding is mentioned in case reports of patients with P. In a systematic review of the literature, platelet counts under 150,000/mm 3 ranged from 24-94% in patients with acute malaria and this frequency was not different between the two major species that affected humans. IVUniversidade de Brasília, Brasília, DF, Brasilĭespite not being a criterion for severe malaria, thrombocytopenia is one of the most common complications of both Plasmodium vivax and Plasmodium falciparum malaria. IIIUniversidade Nilton Lins, Manaus, AM, Brasil IIUniversidade do Estado do Amazonas, Manaus, AM, Brasil ![]() Pedro Teixeira 25, 69040-000 Manaus, AM, Brasil Marcus Vinícius Guimarães LacerdaI, II, I, + +Ĭorresponding Maria Paula Gomes Mourão I, II, III Helena Cristina Cardoso Coelho II João Barberino Santos IV Plasmodium falciparum Plasmodium vivax malaria thrombocytopenia platelets ![]() In a systematic review of the literature, platelet counts under 150,000/mm³ ranged from 24-94% in patients with acute malaria and this frequency was not different between the two major species that affected humans. ![]() Despite not being a criterion for severe malaria, thrombocytopenia is one of the most common complications of both Plasmodium vivax and Plasmodium falciparum malaria.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |